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Intestinal cell proliferation is influenced by intakes of protein and energy, aflatoxin, and Whole-body radiation
- Source :
- Nutrition and Cancer; 1994, Vol. 22 Issue: 1 p11-30, 20p
- Publication Year :
- 1994
-
Abstract
- Intestinal epithelial cell proliferation in young male F344 rats was measured in response to dietary protein content (5%, 10%, and 20% casein diets), energy restriction (energy intake was 60% of ad libitum energy intakes of animals consuming the 20% casein diet), total diet restriction (dietary intake was 60% of the ad libitum intake of 20% casein diet group), aflatoxin administration, and whole body irradiation. Cellular proliferation was measured in sections of jejunum, ileum, proximal colon, and distal colon with the [3H]thymidine technique. Restricting energy or total diet intakes by 40% from ad libitum levels reduced proliferation in epithelial cells throughout the intestine. In comparison to the 5% casein diet, the 20% casein diet resulted in modestly lower cellular proliferation in all intestinal segments. Radiation induced a decrease in cellular proliferation in the jejunum and ileum; this decrease was prevented by a 20% casein diet. Pretreatment with aflatoxin B1 decreased intestinal cell proliferation throughout the intestine, and this decrease was not influenced by the protein content of the diet.
Details
- Language :
- English
- ISSN :
- 01635581 and 15327914
- Volume :
- 22
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Nutrition and Cancer
- Publication Type :
- Periodical
- Accession number :
- ejs19269499
- Full Text :
- https://doi.org/10.1080/01635589409514328