Liquidphase synthesis of mixturebased bicyclic βlactam libraries

Five sets of 27membered combinatorial libraries of alicyclic βlactams were prepared vialiquidphase Ugi 4center 3component reactions U4C3CR utilizing 3 different cisβamino acids, 3 different isonitriles and 5×3 sets of aldehydes. Through combinations of the building blocks of one of these libraries, all of the possible sublibraries were also generated. A few azetidinone derivatives were synthesized individually by parallel synthesis.