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Simple Synthesis of Ruthenium π Complexes of Aromatic Amino Acids and Small Peptides
- Source :
- Chemistry - A European Journal; July 2010, Vol. 16 Issue: 28 p8466-8470, 5p
- Publication Year :
- 2010
-
Abstract
- The interaction of [Ru(η6‐C10H8)(Cp)]+(Cp=C5H5) with aromatic amino acids (L‐phenylalanine, L‐tyrosine, L‐tryptophane, D‐phenylglycine, and L‐threo‐3‐phenylserine) under visible‐light irradiation gives the corresponding [Ru(η6‐amino acid)(Cp)]+complexes in near‐quantitative yield. The reaction proceeds in air at room temperature in water and tolerates the presence of non‐aromatic amino acids (except those which are sulfur containing), monosaccharides, and nucleotides. The complex [Ru(η6‐C10H8)(Cp)]+was also used for selective labeling of Tyr and Phe residues of small peptides, namely, angiotensin I and II derivatives.
Details
- Language :
- English
- ISSN :
- 09476539 and 15213765
- Volume :
- 16
- Issue :
- 28
- Database :
- Supplemental Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Periodical
- Accession number :
- ejs21854754
- Full Text :
- https://doi.org/10.1002/chem.201000520