A Carbohydrate-Linked Cisplatin Analogue Having Antitumor Activity

Authors :: Chen, Yongsheng
Heeg, Mary J.
Braunschweiger, Paul G.
Xie, Wenhua
Wang, Peng G.
Source :: Angewandte Chemie. International Edition; June 14, 1999, Vol. 38 Issue: 12 p1768-1769, 2p
Publication Year :: 1999
Abstract: An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(<SC>II</SC>) complex cis-dichloro[(2-β-<SC>D</SC>-glucopyranosidyl)propane-1,3-diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

Language :: English
ISSN :: 14337851 and 15213773
Volume :: 38
Issue :: 12
Database :: Supplemental Index
Journal :: Angewandte Chemie. International Edition
Publication Type :: Periodical
Accession number :: ejs2255469
Full Text :: https://doi.org/10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6