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Using an Enzyme's Active Site To Template Inhibitors
- Source :
- Angewandte Chemie. International Edition; May 2001, Vol. 40 Issue: 9 p1774-1776, 3p
- Publication Year :
- 2001
-
Abstract
- The irreversible formationof carbonic anhydrase inhibitors from competing building block precursors is templated by the active site of the enzyme itself. The reagents are brought into close proximity of each other in a ternary complex with the enzyme (see scheme).
Details
- Language :
- English
- ISSN :
- 14337851 and 15213773
- Volume :
- 40
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Angewandte Chemie. International Edition
- Publication Type :
- Periodical
- Accession number :
- ejs2257859
- Full Text :
- https://doi.org/10.1002/1521-3773(20010504)40:9<1774::AID-ANIE17740>3.0.CO;2-G