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1-Methylimidazole-catalyzed reaction between tosylmethyl isocyanide and dialkyl acetylenedicarboxylates: An efficient synthesis of functionalized pyrroles
- Source :
- Chinese Chemical Letters; March 2011, Vol. 22 Issue: 3 p314-317, 4p
- Publication Year :
- 2011
-
Abstract
- An efficient 1-methylimidazole-catalyzed synthesis of dialkyl 2-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3,4-dicarboxylates is described. The reactive 1:1 zwitterionic intermediate formed by the addition of 1-methylimidazole to dialkyl acetylenedicarboxylates is trapped by tosylmethyl isocyanide (TOSMIC) to afford the title compounds in excellent yields.
Details
- Language :
- English
- ISSN :
- 10018417
- Volume :
- 22
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Chinese Chemical Letters
- Publication Type :
- Periodical
- Accession number :
- ejs23098171
- Full Text :
- https://doi.org/10.1016/j.cclet.2010.10.032