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Activity of Colistin against Pseudomonas aeruginosa: Inhibition by Calcium
- Source :
- The Journal of Infectious Diseases; December 1971, Vol. 124 Issue: 6 p610-610, 1p
- Publication Year :
- 1971
-
Abstract
- Human serum inhibits the antibacterial activity of colistin and polymyxin B against Pseudomonas aeruginosa</it> in vitro. By use of a colony-count assay, the inhibitory factor in serum was identified as calcium. The bactericidal activity of colistin was inhibited by either 10−3 <scp>m</scp> CaCl<inf>2</inf>, 15% human serum, or 15% heparinized plasma. Colistin was not inhibited by plasma containing chelating agents. Colistin may be less active in vivo than predicted on the basis of in-vitro tests of susceptibility to the antibiotic.
Details
- Language :
- English
- ISSN :
- 00221899 and 15376613
- Volume :
- 124
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- The Journal of Infectious Diseases
- Publication Type :
- Periodical
- Accession number :
- ejs23139745
- Full Text :
- https://doi.org/10.1093/infdis/124.6.610