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Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana
- Source :
- Journal of Natural Products; June 2011, Vol. 74 Issue: 6 p1508-1512, 5p
- Publication Year :
- 2011
-
Abstract
- Investigation of whole plants of Euphorbia fischerianaafforded three new tigliane-diterpenoid glycosides, fischerosides A–C (1–3), together with 11 known diterpenoids. Fischerosides A–C (1–3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1–5. The new compound 3showed an EC50value of 0.02 μM and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.
Details
- Language :
- English
- ISSN :
- 01633864 and 15206025
- Volume :
- 74
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Natural Products
- Publication Type :
- Periodical
- Accession number :
- ejs23744750
- Full Text :
- https://doi.org/10.1021/np200058c