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Fumigaclavine C improves concanavalin A‐induced liver injury in mice mainly via inhibiting TNF‐α production and lymphocyte adhesion to extracellular matrices

Authors :
Zhao, Ying
Liu, Junyan
Wang, Jun
Wang, Lei
Yin, Hao
Tan, Renxiang
Xu, Qiang
Source :
Journal of Pharmacy and Pharmacology; June 2004, Vol. 56 Issue: 6 p775-782, 8p
Publication Year :
2004

Abstract

Fumigaclavine C, an alkaloidal metabolite, was produced by Aspergillus fumigatus(strain No. CY018). This study examined the effect of this compound on concanavalin A (Con A)‐induced liver injury in mice, a T cell‐dependent model of liver damage. Con A administration resulted in severe liver injury, T lymphocyte activation and a strong increment in spleen cell adhesion, as well as in tumour necrosis factor‐α (TNF‐α) production. Against this liver injury, the intraperitoneal administration of fumigaclavine C dose‐dependently inhibited the elevation in transaminase activity, TNF‐α production in serum and the histological changes, including inflammatory infiltration, hepatocyte necrosis and degeneration and Kupffer cell hyperplasia. In addition, this compound in‐vitro also inhibited the proliferation of spleen cells induced by Con A, and reduced their IL‐2 and TNF‐α production. Moreover, the intraperitoneal administration of fumigaclavine C inhibited the potential of spleen cells isolated from the liver‐injured mice to adhere to fibronectin, laminin and type IV collagen. These results suggest that the improvement of this T cell‐mediated liver injury by fumigaclavine C may be related to the inhibition of lymphocyte activation, proliferation and adhesion to extracellular matrices as well as the reduction in TNF‐α production.

Details

Language :
English
ISSN :
00223573 and 20427158
Volume :
56
Issue :
6
Database :
Supplemental Index
Journal :
Journal of Pharmacy and Pharmacology
Publication Type :
Periodical
Accession number :
ejs24053973
Full Text :
https://doi.org/10.1211/0022357023592