Mixed Lymphocyte Cultures and HL-A Identity in Unrelated Subjects

INVESTIGATIONS using highly selected lymphocytotoxic and complement-fixing platelet antibodies have made it possible to define a considerable number of antigens belonging to the HL-A system. These antisera are determined by genetic information belonging to a still unknown number of closely linked loci, subloci or mutational sites. Most of the known HL-A antigens seem to belong to two series, ‘LA’ and ‘4’, each of which contains a number of mutually exclusive genes and corresponding antigens. An ever increasing number of antigens are being identified1–5. The various genes and corresponding antigens, which can be determined, are given in Table 1.