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The Discovery of 5‐Formylcytosine in Embryonic Stem Cell DNA
- Source :
- Angewandte Chemie. International Edition; July 2011, Vol. 50 Issue: 31 p7008-7012, 5p
- Publication Year :
- 2011
-
Abstract
- Touching base: Sophisticated mass spectrometry has shown that 5‐formylcytosine is a constituent of mammalian embryonic stem cell DNA. This base is likely produced from methylcytosine via hydroxymethylcytosine (see scheme), and it may serve as an intermediate in the long searched for pathway of active DNA demethylation.
Details
- Language :
- English
- ISSN :
- 14337851 and 15213773
- Volume :
- 50
- Issue :
- 31
- Database :
- Supplemental Index
- Journal :
- Angewandte Chemie. International Edition
- Publication Type :
- Periodical
- Accession number :
- ejs25452647
- Full Text :
- https://doi.org/10.1002/anie.201103899