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The Discovery of 5‐Formylcytosine in Embryonic Stem Cell DNA

Authors :
Pfaffeneder, Toni
Hackner, Benjamin
Truß, Matthias
Münzel, Martin
Müller, Markus
Deiml, Christian A.
Hagemeier, Christian
Carell, Thomas
Source :
Angewandte Chemie. International Edition; July 2011, Vol. 50 Issue: 31 p7008-7012, 5p
Publication Year :
2011

Abstract

Touching base: Sophisticated mass spectrometry has shown that 5‐formylcytosine is a constituent of mammalian embryonic stem cell DNA. This base is likely produced from methylcytosine via hydroxymethylcytosine (see scheme), and it may serve as an intermediate in the long searched for pathway of active DNA demethylation.

Details

Language :
English
ISSN :
14337851 and 15213773
Volume :
50
Issue :
31
Database :
Supplemental Index
Journal :
Angewandte Chemie. International Edition
Publication Type :
Periodical
Accession number :
ejs25452647
Full Text :
https://doi.org/10.1002/anie.201103899