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771-4 Enhancement of Delayed Afterdepolarlzatlons (DADs) and Triggered Activity by E-4031 and Dofetilide In a Cardiac Glycoside Model of Cell Ca2+Overload
- Source :
- Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p284A-285A, 2p
- Publication Year :
- 1995
-
Abstract
- Several new class III antiarrhythmic drugs, including E-4031 and Dofetilide. are reported to selectively block the rapidly activating delayed rectifier current (iKR). These drugs increase action potential duration (APD) which should load cells with Ca2+via the Na-Ca exchange mechanism and Ca2+channels. Thus DADs, which occur in Ca2+loaded cells, should be enhanced by these drugs.
Details
- Language :
- English
- ISSN :
- 07351097 and 15583597
- Volume :
- 25
- Issue :
- 2, Number 2 Supplement 1
- Database :
- Supplemental Index
- Journal :
- Journal of the American College of Cardiology
- Publication Type :
- Periodical
- Accession number :
- ejs25547902
- Full Text :
- https://doi.org/10.1016/0735-1097(95)92640-Q