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Toward an Image-Guided Microbeam Radiation Therapy Using Gadolinium-Based Nanoparticles

Authors :
Le Duc, Géraldine
Miladi, Imen
Alric, Christophe
Mowat, Pierre
Bräuer-Krisch, Elke
Bouchet, Audrey
Khalil, Enam
Billotey, Claire
Janier, Marc
Lux, François
Epicier, Thierry
Perriat, Pascal
Roux, Stéphane
Tillement, Olivier
Source :
ACS Nano; December 2011, Vol. 5 Issue: 12 p9566-9574, 9p
Publication Year :
2011

Abstract

Ultrasmall gadolinium-based nanoparticles (GBNs) induce both a positive contrast for magnetic resonance imaging and a radiosentizing effect. The exploitation of these characteristics leads to a greater increase in lifespan of rats bearing brain tumors since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is, at the same time, sufficiently high in the tumor and low in the surrounding healthy tissue. GBNs exhibit therefore an interesting potential for image-guided radiotherapy.

Details

Language :
English
ISSN :
19360851 and 1936086X
Volume :
5
Issue :
12
Database :
Supplemental Index
Journal :
ACS Nano
Publication Type :
Periodical
Accession number :
ejs26064375
Full Text :
https://doi.org/10.1021/nn202797h