Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpioexposed in situto surface water treated with chlorine or alternative disinfectants in different seasons

Authors :: Canistro, Donatella
Melega, Simone
Ranieri, Dario
Sapone, Andrea
Gustavino, Bianca
Monfrinotti, Monica
Rizzoni, Marco
Paolini, Moreno
Source :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; January 2012, Vol. 729 Issue: 1-2 p81-89, 9p
Publication Year :: 2012
Abstract: ► Consumption of disinfected drinking water was associated to adverse health outcomes. ► Disinfection by-products are carcinogenic in animal models. ► Cyprinus carpiowere exposed to drinking water in the presence of disinfectants. ► Modulation of liver cytochrome P450s and genotoxic effects were investigated. ► Water disinfection may be responsible of metabolism perturbation and DNA damage.

Language :: English
ISSN :: 13861964
Volume :: 729
Issue :: 1-2
Database :: Supplemental Index
Journal :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publication Type :: Periodical
Accession number :: ejs26445469
Full Text :: https://doi.org/10.1016/j.mrfmmm.2011.09.008

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