Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization

In this study, we test two current models for the function of the tumor suppressor adenomatous polyposis coli (APC). We find that APC can regulate Wnt signaling from diverse cytoplasmic locations, suggesting that its roles in the nucleus or in localizing the β-catenin destruction complex are not essential.