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Intraepithelial Anchoring Fibril Components

Authors :
Goldsmith, Lowell A.
McCoon, Patricia
Partridge, Ann
Lane, Alfred T.
Source :
Archives of Dermatology; January 1991, Vol. 127 Issue: 1 p53-56, 4p
Publication Year :
1991

Abstract

• Cultured human keratinocytes and cultured human cervical carcinoma cells (ME-180) contained intracellular pools of antigens that reacted with the anchoring fibril antibodies AF1 and AF2. In keratinocytes, these antigens formed a basement membrane-like structure near the apical portions of the cells. Using flow cytometric techniques, pretreatment of the ME-180 cells with acetone revealed large intracellular pools of antigen. The intracellular epitope was calcium sensitive. Some forms of recessive dystrophic epidermolysis bullosa have retention of intracellular portions of the anchoring fibril suggesting a relation of the intracellular anchoring fibril antigens to that disease.(Arch Dermatol. 1991;127:53-56)

Details

Language :
English
ISSN :
0003987X and 15383652
Volume :
127
Issue :
1
Database :
Supplemental Index
Journal :
Archives of Dermatology
Publication Type :
Periodical
Accession number :
ejs28480696
Full Text :
https://doi.org/10.1001/archderm.1991.01680010063009