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Morphologic Development of Experimental Cholesteatoma
- Source :
- Archives of Otolaryngology-Head & Neck Surgery; March 1993, Vol. 119 Issue: 3 p272-275, 4p
- Publication Year :
- 1993
-
Abstract
- • Using light microscopy, we studied the morphologic events of cholesteatoma progression 8 months after ligation of the ear canal in 14 Mongolian gerbils. Although we observed a wide range of progression, four stages of morphologic development could be clearly distinguished among the 28 specimens: stage I, an orthokeratotic plug in the ear canal without tympanic membrane involvement; stage II, partial retraction of the tympanic membrane; stage III, the interface between cholesteatoma encapsulated within the tympanic membrane and mucosal membranes covering the promontorial wall of the middle-ear cavity was characterized by a buildup of granulation tissue with prominent macrophage infiltration; and stage IV, bone destruction. Chronic inflammation was observed in some but not all stage II to IV cases. Our results indicate that hyperkeratosis is a primary event in cholesteatoma development, that the development of the granulation tissue with activated macrophages may be responsible for the bone destruction, and that acute or chronic inflammation is not a prerequisite for the development of cholesteatoma or the bone resorptive process.(Arch Otolaryngol Head Neck Surg. 1993;119:272-275)
Details
- Language :
- English
- ISSN :
- 08864470 and 1538361X
- Volume :
- 119
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Archives of Otolaryngology-Head & Neck Surgery
- Publication Type :
- Periodical
- Accession number :
- ejs28600494
- Full Text :
- https://doi.org/10.1001/archotol.1993.01880150020003