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Sudden Sensorineural Hearing Loss and Hemostatic Mechanisms
- Source :
- Archives of Otolaryngology-Head & Neck Surgery; May 1994, Vol. 120 Issue: 5 p536-540, 5p
- Publication Year :
- 1994
-
Abstract
- OBJECTIVE: To evaluate the possible causal role of pathologic hemostatic mechanisms in sudden hearing loss. DESIGN: The study was prospective. SETTING: The patients were hospitalized, and all tests were performed at the hospital. PATIENTS: Thirty-two consecutive patients with sudden hearing loss participated, as well as a control group of 28 healthy individuals. The control group was matched with regard to body mass index. MAIN OUTCOME MEASURES: Venous blood analyses were made regarding general blood parameters, as well as specific hemostatic parameters. RESULTS: Twenty-five of the patients had some kind of aberration of specific hemostasis parameters; seven patients had an increase in the activity of the plasminogen activator inhibitor 1 (ie, a glycoprotein associated with diminished fibrinolysis) compared with that in the control group (P<.05). Increased plasminogen activator inhibitor levels were most frequently observed among the patients who were overweight. Seven of the oldest patients had an increase of D-dimers, ie, a degradation product of fibrin, and most of these patients had a history of cardiovascular disease. CONCLUSION: Although isolated aberrations in the hemostatic pathway were observed, we concluded that pathologic hemostasis does not seem to have a decisive importance for the pathogenesis of sudden deafness.(Arch Otolaryngol Head Neck Surg. 1994;120:536-540)
Details
- Language :
- English
- ISSN :
- 08864470 and 1538361X
- Volume :
- 120
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Archives of Otolaryngology-Head & Neck Surgery
- Publication Type :
- Periodical
- Accession number :
- ejs28600789
- Full Text :
- https://doi.org/10.1001/archotol.1994.01880290046008