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Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1
- Source :
- Molecular Biology of the Cell; February 2013, Vol. 24 Issue: 3 p373-384, 12p
- Publication Year :
- 2013
-
Abstract
- Vaccinia-related kinase 1 (VRK1) is a histone kinase that phosphorylates histone H3 at Thr-3 and Ser-10. This study shows that mitogen-activated protein kinase phosphatase 2 regulates this phosphorylation negatively via interaction with VRK1, regardless of VRK1’s phosphatase activity.
Details
- Language :
- English
- ISSN :
- 10591524 and 19394586
- Volume :
- 24
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Molecular Biology of the Cell
- Publication Type :
- Periodical
- Accession number :
- ejs29412720
- Full Text :
- https://doi.org/10.1091/mbc.e12-06-0456