C3 Glomerulonephritis Associated With Monoclonal Gammopathy: A Case Series

Authors :: Zand, Ladan
Kattah, Andrea
Fervenza, Fernando C.
Smith, Richard J.H.
Nasr, Samih H.
Zhang, Yuzhou
Vrana, Julie A.
Leung, Nelson
Cornell, Lynn D.
Sethi, Sanjeev
Source :: American Journal of Kidney Diseases; September 2013, Vol. 62 Issue: 3 p506-514, 9p
Publication Year :: 2013
Abstract: C3 glomerulonephritis (GN) is a proliferative GN resulting from glomerular deposition of complement factors due to dysregulation of the alternative pathway of complement. Dysregulation of the alternative pathway of complement may occur as a result of mutations or functional inhibition of complement-regulating proteins. Functional inhibition of the complement-regulating proteins may result from a monoclonal gammopathy.