Synthesis, Characterization, DNA-Binding Study of C15H12O4N2 and its Lanthanide Complexes

A new series complexes of Ln nitrate with H₂L, where Ln stands for La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, and H₂L is 2-carboxybenzaldehyde- (4-hydroxy) benzoylhydrazone, were synthesized. Elemental analysis and IR spectroscopy were used to characterize and found that the complexes were Ln (HL)₂(NO₃)·4EtOH·4H₂O type. The binding mode of complexes with CTDNA was investigated by UV-Vis titration and emission titration, suggesting that the complexes bind with CTDNA in a non-covalent groove binding mode.