The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2

This study describes a novel regulatory pathway for the master antioxidant transcription factor Nrf2. The ubiquitin-conjugating enzyme UBE2E3 and its nuclear transport receptor importin-11 coordinately promote the transcriptional activity of Nrf2 by limiting its mitochondrial localization and increasing its residency on target gene promoters.