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Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice
- Source :
- The Journal of Experimental Medicine; February 2015, Vol. 212 Issue: 2 p235-252, 18p
- Publication Year :
- 2015
-
Abstract
- Progressive tissue fibrosis is a cause of major morbidity and mortality. Pulmonary fibrosis is an epithelial-mesenchymal disorder in which TGF-β1 plays a central role in pathogenesis. Here we show that follistatin-like 1 (FSTL1) differentially regulates TGF-β and bone morphogenetic protein signaling, leading to epithelial injury and fibroblast activation. Haplodeletion of Fstl1 in mice or blockage of FSTL1 with a neutralizing antibody in mice reduced bleomycin-induced fibrosis in vivo. Fstl1 is induced in response to lung injury and promotes the accumulation of myofibroblasts and subsequent fibrosis. These data suggest that Fstl1 may serve as a novel therapeutic target for treatment of progressive lung fibrosis.
Details
- Language :
- English
- ISSN :
- 00221007 and 15409538
- Volume :
- 212
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- The Journal of Experimental Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs34877245
- Full Text :
- https://doi.org/10.1084/jem.20121878