Back to Search
Start Over
Persistent Polioviral Infection of the Intact Amniotic Membrane. II. Existence of a Mechanical Barrier to Viral Infection
- Source :
- Experimental Biology and Medicine; December 1966, Vol. 123 Issue: 3 p960-968, 9p
- Publication Year :
- 1966
-
Abstract
- Human amnion cells cultivated in monolayer cultures can easily be infected by poliovirus I, whereas cells of the intact membrane and freshly trypsinized amnion cells are for the most part resistant to infection. Silver impregnation of the histologically intact membrane revealed the presence of a well demarcated intercellular matrix. As the trypsinized amnion cells flatten and spread out on the glass surface, this intercellular substance diminishes considerably, the cells demonstrate marked phagocytic activity and they become susceptible to polioviral infection. It is suggested that this matrix prevents penetration of the virus within the cell either by restricting viral adsorption or by restricting phagocytic activity.
Details
- Language :
- English
- ISSN :
- 15353702 and 15353699
- Volume :
- 123
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Experimental Biology and Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs35579844
- Full Text :
- https://doi.org/10.3181/00379727-123-31648