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Effect of Dietary Vitamin E on Platelet Tocopherol Values and 12-Lipoxygenase Activity
- Source :
- Experimental Biology and Medicine; February 1988, Vol. 187 Issue: 2 p197-201, 5p
- Publication Year :
- 1988
-
Abstract
- This study was designed to evaluate the effects of different amounts of dietary vitamin E on platelet tocopherol levels and 12-lipoxygenase activity when exogenous arachidonic acid was used as substrate. Weanling male Sprague-Dawley rats were fed diets containing 0, 50, and 5000 ppm of D-α-tocopherol acetate for 4 months. Platelet tocopherol was increased with increasing concentrations of dietary vitamin E; however, the conversion of exogenously added arachidonate by platelet to 12-HETE (12-hydroxyeicosatetraenoic acid) and thromboxane B2 from these three dietary groups was essentially the same. This study provides direct evidence that platelet 12-lipoxygenase activity is independent of its vitamin E content when exogenously added arachidonate was used as substrate.
Details
- Language :
- English
- ISSN :
- 15353702 and 15353699
- Volume :
- 187
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Experimental Biology and Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs35603391
- Full Text :
- https://doi.org/10.3181/00379727-187-42654