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Structural insight into the active site of a Bombyx moriunclassified glutathione transferase
- Source :
- Bioscience, Biotechnology, and Biochemistry; June 2015, Vol. 79 Issue: 6 p989-991, 3p
- Publication Year :
- 2015
-
Abstract
- Glutathione transferases (GSTs) are major detoxification enzymes that play central roles in the defense against various environmental toxicants as well as oxidative stress. Here, we identify amino acid residues of an unclassified GST from Bombyx mori, bmGSTu-interacting glutathione (GSH). Site-directed mutagenesis of bmGSTu mutants indicated that amino acid residues Asp103, Ser162, and Ser166 contribute to catalytic activity.
Details
- Language :
- English
- ISSN :
- 09168451 and 13476947
- Volume :
- 79
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Bioscience, Biotechnology, and Biochemistry
- Publication Type :
- Periodical
- Accession number :
- ejs36154804
- Full Text :
- https://doi.org/10.1080/09168451.2014.1002450