First Description of Azole-Resistant Aspergillus fumigatusDue to TR46/Y121F/T289A Mutation in France

ABSTRACTAzole resistance in Aspergillus fumigatusis an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51Agene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatuscarrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillusresistance.