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Dual Invasive Infection with Phaeoacremonium parasiticumand Paraconiothyrium cyclothyrioidesin a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of PhaeoacremoniumPhaeohyphomycosis
- Source :
- Journal of Clinical Microbiology; April 2015, Vol. 53 Issue: 7 p2084-2094, 11p
- Publication Year :
- 2015
-
Abstract
- ABSTRACTDespite increasing reports of human infection, data about the optimal care of Phaeoacremoniuminfections are missing. We report a case of an infection due to Phaeoacremonium parasiticumand Paraconiothyrium cyclothyrioides, initially localized to skin and soft tissue, in a kidney transplant patient. Despite surgical drainage and excision of the lesion and combination antifungal therapy with voriconazole and liposomal amphotericin B, a disseminated infection involving the lungs and brain developed and led to death. We performed a systematic literature review to assess the general features and outcome of human infections due to Phaeoacremoniumspecies. Thirty-six articles were selected, and 42 patients, including ours, were reviewed. Thirty-one patients (74%) were immunocompromised because of organ or bone marrow transplantation (n= 17), diabetes or glucose intolerance (n= 10), rheumatoid arthritis or Still's disease (n= 4), chronic hematological diseases (n= 3), or chronic granulomatous disease (n= 3). Ten patients (24%) reported initial cutaneous trauma. Skin and soft tissue infections represented 57% of infections (n= 24), and disseminated infections, all occurring in immunocompromised patients, represented 14% of infections (n= 6). The main antifungal drugs used were azoles (n= 41) and amphotericin B (n= 16). Surgical excision or drainage was performed in 64% of cases (n= 27). The cure rate was 67% (n= 28). There were 10% cases of treatment failure or partial response (n= 4), 19% relapses (n= 8), and 7% losses to follow-up (n= 3). The death rate was 19% (n= 8). Management of Phaeoacremoniuminfections is complex because of slow laboratory identification and limited clinical data, and treatment relies on a combination of surgery and systemic antifungal therapy.
Details
- Language :
- English
- ISSN :
- 00951137 and 1098660X
- Volume :
- 53
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Journal of Clinical Microbiology
- Publication Type :
- Periodical
- Accession number :
- ejs36189840
- Full Text :
- https://doi.org/10.1128/JCM.00295-15