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Differential effects of nitric oxide synthase inhibitors on endotoxin- induced liver damage in rats

Authors :
Vos, TA
Gouw, AS
Klok, PA
Havinga, R
van Goor, H
Huitema, S
Roelofsen, H
Kuipers, F
Jansen, PL
Moshage, H
Source :
Gastroenterology; October 1997, Vol. 113 Issue: 4 p1323-1333, 11p
Publication Year :
1997

Abstract

BACKGROUND & AIMS: During endotoxemia, expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in the liver is increased. NO has been suggested to have a hepatoprotective function. The aim of this study was to investigate the distribution of iNOS and the effect of different NO synthase inhibitors on liver damage and hemodynamics during endotoxemia.

Details

Language :
English
ISSN :
00165085 and 15280012
Volume :
113
Issue :
4
Database :
Supplemental Index
Journal :
Gastroenterology
Publication Type :
Periodical
Accession number :
ejs36495943
Full Text :
https://doi.org/10.1053/gast.1997.v113.pm9322528