Experiences with Danazol (an antigonadotropin) in the treatment of infertility

An antigonadotropic agent, Danazol, was used in the management of 48 patients with either primary or secondary sterility. All patients were infertile for 3 or more years before Danazol was employed. In Group 1, 11 of 21 had proved endometriosis histologically; the rest had suspected endometriosis by history and examination. In the second group of 27, no reason for infertility was found. A dose of 200 mg. was given orally for 100 days to all patients, but, in the group with endometriosis, the dosage was increased to 400 mg. in 3 and 800 mg. in 5 in order to induce abatement of severe pelvic discompfort. None conceived while on therapy while about 40 per cent did conceive within 4 months after discontinuation of the drug.