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Experiences with Danazol (an antigonadotropin) in the treatment of infertility

Authors :
Greenblatt, Robert B.
Borenstein, Richard
Hernandez-Ayup, Samuel
Source :
American Journal of Obstetrics and Gynecology; March 1974, Vol. 118 Issue: 6 p783-787, 5p
Publication Year :
1974

Abstract

An antigonadotropic agent, Danazol, was used in the management of 48 patients with either primary or secondary sterility. All patients were infertile for 3 or more years before Danazol was employed. In Group 1, 11 of 21 had proved endometriosis histologically; the rest had suspected endometriosis by history and examination. In the second group of 27, no reason for infertility was found. A dose of 200 mg. was given orally for 100 days to all patients, but, in the group with endometriosis, the dosage was increased to 400 mg. in 3 and 800 mg. in 5 in order to induce abatement of severe pelvic discompfort. None conceived while on therapy while about 40 per cent did conceive within 4 months after discontinuation of the drug.

Details

Language :
English
ISSN :
00029378 and 10976868
Volume :
118
Issue :
6
Database :
Supplemental Index
Journal :
American Journal of Obstetrics and Gynecology
Publication Type :
Periodical
Accession number :
ejs36797465
Full Text :
https://doi.org/10.1016/0002-9378(74)90488-8