The role of fibronectin in fibroblast migration during tissue repair

Tissue repair begins with the formation of a blood clot, and moves through the stages of chemotaxis, migration of neutrophils, macrophages and fibroblasts, angio genesis, formation of a provisional matrix, synthesis of collagen, assembly of collagen matrix, migration and proliferation of keratinocytes and, finally, wound closure. Each process requires groups of cells to perform various functions in consort and is controlled by growth factors and cytokines through cell signalling.