The effect of food on the in vivo behaviour of a novel sustained release formulation of tiaprofenic acid

A novel sustained release tablet formulation of tiaprofenic acid, that has been designed to disintegrate into discrete pellets in the gastrointestinal tract, has been evaluated using a combination of gamma scintigraphy and pharmacokinetics. The performance of the product in vivo was very satisfactory, in that the disintegration of the tableted pellet formulation was rapid. The gastrointestinal transit behaviour of pellets was affected by food, but food did not affect the subsequent absorption of the released drug.