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Organocatalytic Synthesis of Fused Bicyclic 2,3-Dihydro-1,3,4-oxadiazoles through an Intramolecular Cascade Cyclization

Authors :
Fugard, Alison J.
Thompson, Bethany K.
Slawin, Alexandra M. Z.
Taylor, James E.
Smith, Andrew D.
Source :
Organic Letters; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

Hydrazone-carboxylic acids undergo intramolecular cyclization in the presence of pivaloyl chloride, iPr2NEt, and catalytic DABCO to form a range of substituted fused tricyclic 2,3-dihydro-1,3,4-oxadiazoles in high yields.

Details

Language :
English
ISSN :
15237060 and 15237052
Issue :
Preprints
Database :
Supplemental Index
Journal :
Organic Letters
Publication Type :
Periodical
Accession number :
ejs37305907
Full Text :
https://doi.org/10.1021/acs.orglett.5b02997