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Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity
- Source :
- Journal of Chemistry; 2015, Vol. 2015 Issue: 1
- Publication Year :
- 2015
-
Abstract
- Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia. However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo. Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca2+ concentration together with Ca2+-ATPase activity. The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca2+ level, and improving Ca2+-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease.
Details
- Language :
- English
- ISSN :
- 20909063 and 20909071
- Volume :
- 2015
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs37506812
- Full Text :
- https://doi.org/10.1155/2015/497842