Role of Inter-Observer Variability and Quantification of Muscularis Propria in the Pathological Staging of Bladder Cancer

We showed that the implementation of dedicated genito-urinary pathologists is able to improve inter-observer variability in the pathological staging of bladder cancer. In addition, we show that the mere presence of muscularis propria bundles in trans-urethral bladder resection specimens significantly predicts stage at radical cystectomy. We enrolled, for this purpose, 101 patients with histologically diagnosis of pT1 bladder cancer who invariably underwent radical cystectomy in the course of disease.