Effect of Formulation and Process Variables on Bioequivalency of Nitrofurantoin II: In Vivo-In VitroCorrelation

Based on preliminary in vitroevaluation, six formulations presenting a broad range of dissolution rates were selected for bioequivalency determination in a randomized complete block crossover. In vitro-in vivocorrelations were developed relating cumulative percent dissolved to cumulative percent excreted. These correlations appear to be useful for comparing different formulations as well as different batches of the same formulation.