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Patients with Rheumatoid Arthritis and Gold-induced Pneumonitis Express Two High-risk Major Histocompatibility Complex Patterns
- Source :
- Chest; August 1987, Vol. 92 Issue: 2 p277-281, 5p
- Publication Year :
- 1987
-
Abstract
- Gold salt therapy-induced pneumonitis is a rare complication in patients with rheumatoid arthritis (RA). We studied HLA-A, B, C, D/DR, and complement factor B (Bf) and C4 alleles in 17 patients with RA and gold-induced pneumonitis and found that these patients had strikingly homogeneous major histocompatibility complex (MHC) markers. Eight of them (47 percent) had the alleles HLA-A3 B35 Dw1 BfF C4A3,2 (BO) which were shown by family studies of some patients to be inherited as an extended MHC-haplotype with an apparent gene duplication in the C4A locus. The other high-risk phenotype, HLA-B40 with a C4 null allele, was found in eight patients (47 percent.) All but three of the 17 patients had at least one of the two high-risk markers, the frequency of these combinations being clearly higher than in the two control groups: patients with RA but with no gold-induced side effects and healthy individuals. Our study shows that use of several MHC markers together results in a strong association between the markers and the disease.
Details
- Language :
- English
- ISSN :
- 00123692 and 19313543
- Volume :
- 92
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Chest
- Publication Type :
- Periodical
- Accession number :
- ejs37961441
- Full Text :
- https://doi.org/10.1378/chest.92.2.277