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Patients with Rheumatoid Arthritis and Gold-induced Pneumonitis Express Two High-risk Major Histocompatibility Complex Patterns

Authors :
Partanen, Jukka
van Assendelft, Alexander H.W.
Koskimies, Saija
Forsberg, Sinikka
Hakala, Markku
Ilonen, Jorma
Source :
Chest; August 1987, Vol. 92 Issue: 2 p277-281, 5p
Publication Year :
1987

Abstract

Gold salt therapy-induced pneumonitis is a rare complication in patients with rheumatoid arthritis (RA). We studied HLA-A, B, C, D/DR, and complement factor B (Bf) and C4 alleles in 17 patients with RA and gold-induced pneumonitis and found that these patients had strikingly homogeneous major histocompatibility complex (MHC) markers. Eight of them (47 percent) had the alleles HLA-A3 B35 Dw1 BfF C4A3,2 (BO) which were shown by family studies of some patients to be inherited as an extended MHC-haplotype with an apparent gene duplication in the C4A locus. The other high-risk phenotype, HLA-B40 with a C4 null allele, was found in eight patients (47 percent.) All but three of the 17 patients had at least one of the two high-risk markers, the frequency of these combinations being clearly higher than in the two control groups: patients with RA but with no gold-induced side effects and healthy individuals. Our study shows that use of several MHC markers together results in a strong association between the markers and the disease.

Details

Language :
English
ISSN :
00123692 and 19313543
Volume :
92
Issue :
2
Database :
Supplemental Index
Journal :
Chest
Publication Type :
Periodical
Accession number :
ejs37961441
Full Text :
https://doi.org/10.1378/chest.92.2.277