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Amino acid derivatives of pyropheophorbide-aethers as photosensitizer: Synthesis and photodynamic activity
- Source :
- Chinese Chemical Letters; May 2016, Vol. 27 Issue: 5 p623-626, 4p
- Publication Year :
- 2016
-
Abstract
- Ten new water-soluble amino acid derivatives of pyropheophorbide-aethers 4a–4jwere designed and synthesized via3 steps reaction using pyropheophorbide-aas key intermediate. All target compounds exhibited better phototoxicity than BPD-MA and the most phototoxic compound 4dand 4jindividually showed IC50values of 41nmol/L and 33nmol/L against HCT116 cell, which represented 7.8- and 9.7-fold increase of antitumor potency compared to BPD-MA.
Details
- Language :
- English
- ISSN :
- 10018417
- Volume :
- 27
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Chinese Chemical Letters
- Publication Type :
- Periodical
- Accession number :
- ejs38376651
- Full Text :
- https://doi.org/10.1016/j.cclet.2016.03.019