Low prevalence of clarithromycin-resistant Helicobacter pyloriisolates with A2143G point mutation in the 23S rRNA gene in North India

•High prevalence of clarithromycin-sensitive H. pyloristrains allows use of this drug.•Surveillance studies need to be done at regular intervals.•First study on the mechanism of clarithromycin resistance in India.•Mutations A2143G and A2142G are associated with clarithromycin resistance.