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BACH2 regulates CD8+T cell differentiation by controlling access of AP-1 factors to enhancers
- Source :
- Nature Immunology; July 2016, Vol. 17 Issue: 7 p851-860, 10p
- Publication Year :
- 2016
-
Abstract
- T cell activation upon TCR signaling can lead to development of effector and memory cells. Roychoudhuri and colleagues show that the transcription factor BACH2 promotes memory CD8+T cell generation by blocking access to genomic regulatory sites recognized by AP-1.
Details
- Language :
- English
- ISSN :
- 15292908 and 15292916
- Volume :
- 17
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Nature Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs39411959
- Full Text :
- https://doi.org/10.1038/ni.3441