Back to Search
Start Over
p53 induces formation of NEAT1lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity
- Source :
- Nature Medicine; August 2016, Vol. 22 Issue: 8 p861-868, 8p
- Publication Year :
- 2016
-
Abstract
- Silencing expression of the long noncoding RNA NEAT1prevents paraspeckle formation and sensitizes neoplastic cells to DNA-damage-induced cell death. NEAT1expression also predicts chemotherapy response in ovarian cancer patients.
Details
- Language :
- English
- ISSN :
- 10788956 and 1546170X
- Volume :
- 22
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Nature Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs39753467
- Full Text :
- https://doi.org/10.1038/nm.4135