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Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors
- Source :
- Chinese Chemical Letters; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities.
Details
- Language :
- English
- ISSN :
- 10018417
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Chinese Chemical Letters
- Publication Type :
- Periodical
- Accession number :
- ejs39988119
- Full Text :
- https://doi.org/10.1016/j.cclet.2016.09.001