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Somatic POLEproofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
- Source :
- The Lancet Gastroenterology & Hepatology; November 2016, Vol. 1 Issue: 3 p207-216, 10p
- Publication Year :
- 2016
-
Abstract
- Precision cancer medicine depends on defining distinct tumour subgroups using biomarkers that may occur at very modest frequencies. One such subgroup comprises patients with exceptionally mutated (ultramutated) cancers caused by mutations that impair DNA polymerase epsilon (POLE) proofreading.
Details
- Language :
- English
- ISSN :
- 24681253
- Volume :
- 1
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- The Lancet Gastroenterology & Hepatology
- Publication Type :
- Periodical
- Accession number :
- ejs40206393
- Full Text :
- https://doi.org/10.1016/S2468-1253(16)30014-0