235 Neurosensory Impairment and Treament of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants

Background and aim: There is controversy in the last years on on surgical closure of the ductus arteriosus in extremely low birth weight infants. Study the possible consequences of surgical closure of the patent ductus arteriosus in the newborn period.Material and methods: 422 preterm newborns born with of less than 1000 gr. were studied, 202 (47,86 %) had symptomatic PDA (Patent Ductus Arteriosus) and received medical therapy with indomethacine., 36 (8,53 %) underwent PDA ligation. We studied the risks of adverse outcomes (Retinopathy (ROP), bronchopulmonary dysplasia (BDP), and Neurosensory Impairment (NI)) between both groups, surgical closure and non surgical treatment.Results: No significant differences between the two groups were found in: Maternal age, gestations, gestacional age, type of delivery, pH at delivery, Apgar score at 1 and 5 minutes, weight, height and cephalic perimeter. ROP, Intracraneal hemorrage, neumothorax, necrotaizing enterocolitis, had no different incidences in both groups. We found augmented risk in surgery closure group : Lenth of stay (LOS) in hospital 99,5±6,46 versus 69,50±3,59 (p< 0,001), NI Odds ratio 3,149 (1,286-7,712) and BDP 2,364 (1,085-5,151).Conclusions: PDA surgical closure seems that can be associated with increased risk of LOS, NI and BDP in this group of infants. We could not demonstrate, like other authors have, its relationship with ROP.