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Multilocus Phylogeny and Antifungal Susceptibility of AspergillusSection Circumdatifrom Clinical Samples and Description of A. pseudosclerotiorumsp. nov
- Source :
- Journal of Clinical Microbiology; February 2017, Vol. 55 Issue: 3 p947-958, 12p
- Publication Year :
- 2017
-
Abstract
- ABSTRACTA multilocus phylogenetic study was carried out to assess species identity of a set of 34 clinical isolates from Aspergillussection Circumdatifrom the United States and to determine their in vitroantifungal susceptibility against eight antifungal drugs. The genetic markers used were the internal transcribed spacer (ITS) region, and fragments of the beta-tubulin (BenA), calmodulin (CaM), and RNA polymerase II second largest subunit (RPB2) genes. The drugs tested were amphotericin B, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, and terbinafine. The most common species sampled was A. westerdijkiae(29.4%), followed by a novel species, which was described here as A. pseudosclerotiorum(23.5%). Other species identified were A. sclerotiorum(17.6%), A. ochraceus(8.8%), A. subramanianii(8.8%), and A. insulicolaand A. ochraceopetaliformis, with two isolates (5.9%) of each. The drugs that showed the most potent activity were caspofungin, micafungin, and terbinafine, while amphotericin B showed the least activity.
Details
- Language :
- English
- ISSN :
- 00951137 and 1098660X
- Volume :
- 55
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Clinical Microbiology
- Publication Type :
- Periodical
- Accession number :
- ejs41408015
- Full Text :
- https://doi.org/10.1128/JCM.02012-16