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Sensitization of Radiation or Gemcitabine-Based Chemoradiation Therapeutic Effect by Nimotuzumab in Pancreatic Cancer Cells
- Source :
- Technology in Cancer Research & Treatment; June 2016, Vol. 15 Issue: 3 p446-452, 7p
- Publication Year :
- 2016
-
Abstract
- This study was performed to observe the effect of the combination of nimotuzumab with radiation or gemcitabine-based chemoradiation on antipancreatic cancer cell therapy. Pancreatic cancer cells (PANC-1) were treated with nimotuzumab alone or combined with radiation (2, 4, or 8 Gy), which was either with or without gemcitabine chemotherapy. Cell proliferation, cell cycle distribution, and apoptosis were observed. The inhibition rate, the percentage of G2/M phase arrest, and the apoptosis rate of the combined nimotuzumab with radiation group was significantly higher than the group without nimotuzumab (P< .001). The inhibition rate, the percentage of G2/M phase, and the apoptosis rate of the nimotuzumab therapy combined with gemcitabine-based chemoradiation group were obviously higher than that in gemcitabine-based chemoradiation group (P< .001). In conclusion, nimotuzumab could enhance the anticancer effect of radiation and gemcitabine-based chemoradiation in PANC-1 cancer cells because of the enhancement of cell cycle arrest and apoptosis.
Details
- Language :
- English
- ISSN :
- 15330346 and 15330338
- Volume :
- 15
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Technology in Cancer Research & Treatment
- Publication Type :
- Periodical
- Accession number :
- ejs42280225
- Full Text :
- https://doi.org/10.1177/1533034615585209