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Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a PaecilomycesSpecies
- Source :
- Journal of Natural Products; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N–P (1–3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4′-hydroxymonocillin IV (7), and 4′-methoxymonocillin IV (8), along with nine known RALs (9–17), were isolated from the cultures of Paecilomycessp. SC0924. Compounds 1and 2feature a novel 6/11/5 ring system, and 3is the first 5′-keto RAL. The structures of 1–8were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5and 7display antifungal activity against Peronophythora litchii.
Details
- Language :
- English
- ISSN :
- 01633864 and 15206025
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Natural Products
- Publication Type :
- Periodical
- Accession number :
- ejs42861975
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.7b00066