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PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network

Authors :
Shiwarski, Daniel J.
Darr, Marlena
Telmer, Cheryl A.
Bruchez, Marcel P.
Puthenveedu, Manojkumar A.
Source :
Molecular Biology of the Cell; 2017, Vol. 28 Issue: 16 p2202-2219, 18p
Publication Year :
2017

Abstract

The δ-opioid receptor (δR) is retained in intracellular structures in neurons, but the mechanisms of retention and regulated export are not known. The atypical phosphoinositide-3 kinase C2A is required and sufficient for NGF-regulated δR export from the trans-Golgi network and surface transport.

Details

Language :
English
ISSN :
10591524 and 19394586
Volume :
28
Issue :
16
Database :
Supplemental Index
Journal :
Molecular Biology of the Cell
Publication Type :
Periodical
Accession number :
ejs42862183
Full Text :
https://doi.org/10.1091/mbc.E17-01-0030