Back to Search
Start Over
Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production
- Source :
- Journal of Innate Immunity; November 2017, Vol. 9 Issue: 6 p529-545, 17p
- Publication Year :
- 2017
-
Abstract
- In this paper, we report previously unknown roles for collectin-11 (CL-11, a soluble C-type lectin) in modulating the retinal pigment epithelial (RPE) cell functions of phagocytosis and cytokine production. We found that CL-11 and its carbohydrate ligand are expressed in both the murine and human neural retina; these resemble each other in terms of RPE and photoreceptor cells. Functional analysis of murine RPE cells showed that CL-11 facilitates the opsonophagocytosis of photoreceptor outer segments and apoptotic cells, and also upregulates IL-10 production. Mechanistic analysis revealed that calreticulin on the RPE cells is required for CL-11-mediated opsonophagocytosis whereas signal-regulatory protein α and mannosyl residues on the cells are involved in the CL-11-mediated upregulation of IL-10 production. This study is the first to demonstrate the role of CL-11 and the molecular mechanisms involved in modulating RPE cell phagocytosis and cytokine production. It provides a new insight into retinal health and disease and has implications for other phagocytic cells.
Details
- Language :
- English
- ISSN :
- 1662811X and 16628128
- Volume :
- 9
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Innate Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs42900493
- Full Text :
- https://doi.org/10.1159/000478042