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A Chemoselective N-Arylation Reaction of 2-Aminopyridine Derivatives with Arynes

Authors :
Cheng, Bin
Wei, Jian
Zu, Bing
Zhao, Jianfei
Wang, Taimin
Duan, Xiaoguang
Wang, Renqi
Li, Yun
Zhai, Hongbin
Source :
The Journal of Organic Chemistry; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

A chemoselective N-arylation reaction of 2-aminopyridine derivatives with arynes in good to excellent yields has been described. The N-arylation products could be further applied to the facile construction of benzoisoquinuclidines and isoquinuclidines as well as pyrido[1,2-a]benzimidazoles.

Details

Language :
English
ISSN :
00223263
Issue :
Preprints
Database :
Supplemental Index
Journal :
The Journal of Organic Chemistry
Publication Type :
Periodical
Accession number :
ejs42971084
Full Text :
https://doi.org/10.1021/acs.joc.7b01405